Fourth International Symposium on Sigma-2 Receptors

The Fourth International Symposium on Sigma-2 Receptors: Role in Health and Disease

A Satellite Symposium of the Society for Neuroscience’s Annual ‘Neuroscience 2019’ Conference

Recent advances in the molecular identification of the sigma-2 receptor as TMEM97 and the role of PGRMC1 in its function are opening new areas of discovery. This satellite symposium highlights the roles of the sigma-2/PGRMC1 receptor complex in clinically important areas such as synaptic regulation, pain, metabolic activity and oncology, which are relevant to treating a diverse range of diseases from cancer to Alzheimer’s disease with discoveries from cells to the clinic.



Friday, October 18, 2019
10:00 a.m. – 4:00 p.m.
please note revised start time

Loyola University Medical School
Center for Translational Research and Education
2160 S First Avenue
Maywood, IL
(Parking Lot A)


10:00 a.m.
Refreshments and Registration
10:30 a.m.
Welcome Statement

Meharvan Singh, Ph.D.
Loyola University Chicago

10:40 a.m.
Opening Remarks

Susan Catalano, Ph.D.
Cognition Therapeutics

10:50 a.m.

Characterization of Sigma-2 Receptor Ligand-induced Metabolic Stimulation in Human SK-N-SH Neuroblastoma Cells

Wayne D. Bowen, Ph.D.
Brown University

11:15 a.m.

TMEM-97 Synaptic Localization and Potential Amyloid Beta Interaction in Human Alzheimer’s Disease Cases

Martí Colom Cadena, Ph.D.
University of Edinburgh

11:40 a.m.

The Sigma-2 Receptor/TMEM97, PGRMC1 and LDL Receptor Complex are Responsible for the Cellular Uptake of Aβ42 and its Protein Aggregates

Aladdin A. Riad, Ph.D.
University of Pennsylvania

12:05 p.m.

Quantitative Autoradiography of Sigma Receptors in Postmortem Brains

Jinbin Xu, Ph.D.
Washington University

12:30 p.m.
Lunch in the Alumni Lounge
1:35 p.m.

Inhibition of miRNA let7i Enhances the Progesterone-induced Neuroprotection

Meharvan Singh, Ph.D.
Loyola University Chicago

2:00 p.m.

Modifying Sigma-2 Receptor Lead-Compounds to Produce Differently Purposed Sigma-2 Targeted Agents

Carmen Abate, Ph.D.
Università degli Studi di Bari

2:25 p.m.

Metabolomic Evidence of Disease Modification in Mild-to-Moderate AD Patients by Sigma-2 Antagonist CT1812

Nicholas J. Izzo, Ph.D.
Cognition Therapeutics

2:50 p.m.

Clinical Biomarker Evidence for Target Engagement, Reduction of Synaptic Damage and Disease Modification in Alzheimer’s Patients Treated with CT1812

Susan Catalano, Ph.D.
Cognition Therapeutics

3:15 p.m.

The Grand-scale Biology of PGRMC1: How Eukaryogenesis and the Ediacaran Fauna Illuminate S2R-associated Pathologies like Cancer and Dementia

Michael A. Cahill, Ph.D.
Charles Sturt University

3:45 p.m.

Closing Remarks

Robert H. Mach, Ph.D.
University of Pennsylvania

4:00 p.m.

The event is listed on the Society for Neuroscience’s webpage of satellite events and is open to all meeting attendees.

Please register below so that we may maintain an accurate headcount.
Registrants will also receive additional information about the symposium speakers and agenda by email.    

thank you

We will keep you apprised as details of the International Symposium on Sigma-2 Receptors become available.