About Us

Cognition Therapeutics, Inc. is a clinical stage neuroscience company developing drugs that help restore normal cellular damage responses in neurodegenerative and neuro-ophthalmic disorders.
The company’s candidates work by binding to protein components of the σ-2 (sigma-2) receptor complex, which is present on synapses and acts as a key regulator of cellular damage and stress response. Receptor component proteins (PGRMC1 and TMEM97) control autophagy, cholesterol synthesis and lipid membrane-bound protein trafficking, all of which are associated with age-related central nervous system (CNS) disorders.
Lead Candidate – CT1812
Cognition’s lead candidate, CT1812, is an orally delivered, first-in-class, brain-penetrant small molecule drug designed to bind selectively to the σ-2 receptor complex. By so doing, the aim is to restore the damaged cellular processes that drive diseases such as Alzheimer’s disease, dry age-related macular degeneration (dry AMD), geographic atrophy and other conditions. To learn more about our ongoing and planned clinical studies, please visit our Pipeline.
Review of Cognition’s foundational science, told by co-founder, Susan Catalano, PhD.
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Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.

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Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.

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Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.

You are now leaving the Cognition Therapeutics website

Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.

You are now leaving the Cognition Therapeutics website

You are now leaving the Cognition Therapeutics website

Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.

You are now leaving the Cognition Therapeutics website

Cognition Therapeutics assumes no responsibility for the content of third-party website. Neither does Cognition control, endorse or guarantee any aspect of your use of third-party sites. We encourage you to read and evaluate terms of use, privacy and other policies of the destination site as they may differ from Cognition’s policies.