The following video archives are available from:

The Third International Symposium on Sigma-2 Receptors:
Role in Health and Disease

November 3, 2018

Symposium Booklet:
Introductory statement
Speaker biographies

Videos of individual speakers may be viewed below:

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Introduction to Session and Speakers

Susan Catalano, Ph.D.
Chief Science Officer and Founder, Cognition Therapeutics, Inc.

Biography of Dr. Catalano
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Differential Sigma-2 Receptor/TMEM97-Mediated Cytotoxic and Metabolic Stimulative Properties of Monovalent and Bivalent SN79 Analogs
Wayne D. Bowen, Ph.D.
Upjohn Professor of Pharmacology, Professor of Biology, Chair of the Department of Molecular Pharmacology, Physiology & Biotechnology,
Brown University
Biography of Dr. Bowen
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Targeting Sigma-2 Receptor (σ2R)/TMEM97 to Address Unmet Medical Needs in Neuroscience
Stephen F. Martin, Ph.D.
M. June and J. Virgil Waggoner Regents Chair in Chemistry
University of Texas at Austin
Biography of Dr. Martin
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Sigma 2 Receptor-Interacting Protein PGRMC1 is Descended from the Hopanoid Synthetic Pathway of the Endosymbiotic Proto-Mitochondrion
Michael A. Cahill, Ph.D.
Lecturer in Biochemistry and Cell Biology
Charles Sturt University, New South Wales, Australia
Biography of Dr. Cahill
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Let7i as a Key Regulator of PGRMC1 and Progesterone-Induced Neuroprotection
Meharvan “Sonny” Singh, Ph.D.
Professor, Department of Pharmacology and Neuroscience, Interim Executive Director, Institute for Healthy Aging
University of North Texas Health Science Center
Biography of Dr. Singh
Play Video
Clinical Evidence of Synaptic Protection in Alzheimer’s Patients following Treatment of CT1812
Susan Catalano, Ph.D.
Chief Science Officer and Founder
Cognition Therapeutics, Inc.
Biography of Dr. Catalano
Play Video
Sigma-2 Antagonist CT1812 Protects Synapses from Abeta Oligomer-Induced Loss, In Vitro
Nicholas J. Izzo, Ph.D.
Principal Scientist and Director of Screening
Cognition Therapeutics, Inc.

Biography of
Dr. Izzo

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KEYNOTE ADDRESS: APOE4 Associated Changes in the Synaptic Proteome in Human Alzheimer’s Disease Brain
Tara Spires-Jones, DPhil
Professor of Neurodegeneration at the UK Dementia Research Institute Programme, Lead Deputy Director of the Centre for Discovery Brain Sciences
University of Edinburgh, Scotland

Biography of
Dr. Spires-Jones

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The Essential Role of Sigma-2 Receptor/TMEM97 and Progesterone Receptor Membrane Component 1 in the Internalization of Low-Density Lipoprotein via and Interaction with the Low-Density Lipoprotein Receptor
Aladdin A. Riad, Ph.D.
Postdoctoral Fellow
University of Pennsylvania

Biography of
Dr. Riad

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A Novel Mechanism Underlying Synaptic Plasticity: Roles for PGRMC1 and TMEM97?
Timothy E. Kennedy, Ph.D.
co-Director, McGill Program in Neuroengineering; Professor, Department of Neurology and Neurosurgery; Professor, Department of Anatomy and Cell Biology
Montreal Neurological Institute
McGill University, Montreal, Quebec, Canada

Biography of
Dr. Kennedy

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Biological Roles of TMEM97 and PGRMC1 in Cell Growth and Sigma-2 Ligand-Induced Cell Death
Chenbo Zeng, Ph.D.
Research Assistant Professor of Radiology
University of Pennsylvania

Biography of
Dr. Zeng

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Identification of a Second [3H]DTG Binding Site on TMEM97-KO Cell Membranes
Robert H. Mach, Ph.D.
Britton Chance Professor of Radiology
University of Pennsylvania

Biography of
Dr. Mach

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